Adla P, Bshivakumar V, Pathak D, Mattam U, Tammineni P, Krishnamoorthy T, Sepuri NBV. A new subset of mitochondrial-derived vesicles perform inter-mitochondrial communications. Mol Biol Cell. 2025 Dec 24:mbcE25040188. doi: 10.1091/mbc.E25-04-0188. PMID: 41442151.
Boggula Y, Chatterjee A, Simaiya G, Pal A, Srinivasan A, Sepuri NBV. Lon/Pim1-mediated degradation of presequence translocase-associated motor components Pam16 and Pam18 in Saccharomyces cerevisiae. Biochem J. 2025 Nov 4;482(21):1645–58. doi: 10.1042/BCJ20243016. PMID: 41099349; PMCID: PMC12687454.
Velagapudi S, Miranda MX, Adla P, Kraler S, Mohammed SA, Baki S, Robert J, Rohrer L, Lee H, Jang HD, Obeid S, Tailleux A, Staels B, Sepuri NBV, Paneni F, Gutti RK, von Eckardstein A, Kim HS, Akhmedov A, Camici GG, Lüscher TF. Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation. Cardiovasc Res. 2025 Aug 14;121(9):1373-1384. doi: 10.1093/cvr/cvaf087. PMID: 40653676; PMCID: PMC12352300.
Chatterjee A, Sepuri NBV. Methionine sulfoxide reductase 2 regulates Cvt autophagic pathway by altering the stability of Atg19 and Ape1 in Saccharomyces cerevisiae. J Biol Chem. 2024 Mar;300(3):105662. doi: 10.1016/j.jbc.2024.105662. Epub 2024 Jan 20. PMID: 38246354; PMCID: PMC10875273.
Pathak D, Krishnamoorthy T, Sepuri NBV. Analysis of mitochondrial biogenesis regulation by oxidative stress. Methods Enzymol. 2024;707:519-539. doi: 10.1016/bs.mie.2024.07.060. Epub 2024 Aug 26. PMID: 39488389.
Talari NK, Mattam U, Meher NK, Paripati AK, Mahadev K, Krishnamoorthy T, Sepuri NBV. Lipid-droplet associated mitochondria promote fatty-acid oxidation through a distinct bioenergetic pattern in male Wistar rats. Nat Commun. 2023 Feb 11;14(1):766. doi: 10.1038/s41467-023-36432-0. PMID: 36765117; PMCID: PMC9918515.
Pal A, Paripati AK, Deolal P, Chatterjee A, Prasad PR, Adla P, Sepuri NBV. Eisosome protein Pil1 regulates mitochondrial morphology, mitophagy, and cell death in Saccharomyces cerevisiae. J Biol Chem. 2022 Nov;298(11):102533. doi: 10.1016/j.jbc.2022.102533. Epub 2022 Sep 24. PMID: 36162502; PMCID: PMC9619184.
Koncha RR, Ramachandran G, Sepuri NBV, Ramaiah KVA. CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis. FEBS J. 2021 Oct;288(19):5737-5754. doi: 10.1111/febs.15868. Epub 2021 Apr 27. PMID: 33837631.
Mattam U, Talari NK, Thiriveedi VR, Fareed M, Velmurugan S, Mahadev K, Sepuri NBV. Aging reduces kisspeptin receptor (GPR54) expression levels in the hypothalamus and extra-hypothalamic brain regions. Exp Ther Med. 2021 Sep;22(3):1019. doi: 10.3892/etm.2021.10451. Epub 2021 Jul 15. PMID: 34373705; PMCID: PMC8343700.
Mattam U, Talari NK, Paripati AK, Krishnamoorthy T, Sepuri NBV. Kisspeptin preserves mitochondrial function by inducing mitophagy and autophagy in aging rat brain hippocampus and human neuronal cell line. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118852. doi: 10.1016/j.bbamcr.2020.118852. Epub 2020 Sep 11. PMID: 32926943.
Thiriveedi VR, Mattam U, Pattabhi P, Bisoyi V, Talari NK, Krishnamoorthy T, Sepuri NBV. Glutathionylated and Fe-S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain. Redox Biol. 2020 Oct;37:101725. doi: 10.1016/j.redox.2020.101725. Epub 2020 Sep 15. PMID: 32971361; PMCID: PMC7511737.
Mohammed F, Gorla M, Bisoyi V, Tammineni P, Sepuri NBV. Rotenone-induced reactive oxygen species signal the recruitment of STAT3 to mitochondria. FEBS Lett. 2020 May;594(9):1403-1412. doi: 10.1002/1873-3468.13741. Epub 2020 Feb 18. PMID: 31981230.
Karri S, Singh S, Paripati AK, Marada A, Krishnamoorthy T, Guruprasad L, Balasubramanian D, Sepuri NBV. Adaptation of Mge1 to oxidative stress by local unfolding and altered Interaction with mitochondrial Hsp70 and Mxr2. Mitochondrion. 2019 May;46:140-148. doi: 10.1016/j.mito.2018.04.003. Epub 2018 Apr 9. PMID: 29649582.
Allu PK, Boggula Y, Karri S, Marada A, Krishnamoorthy T, Sepuri NBV. A conserved R type Methionine Sulfoxide Reductase reverses oxidized GrpEL1/Mge1 to regulate Hsp70 chaperone cycle. Sci Rep. 2018 Feb 9;8(1):2716. doi: 10.1038/s41598-018-21083-9. PMID: 29426933; PMCID: PMC5807549.
Sepuri NBV, Tammineni P, Mohammed F, Paripati A. Nuclear Transcription Factors in the Mitochondria: A New Paradigm in Fine-Tuning Mitochondrial Metabolism. Handb Exp Pharmacol. 2017;240:3-20. doi: 10.1007/164_2016_3. PMID: 27417432.
Marada A, Karri S, Singh S, Allu PK, Boggula Y, Krishnamoorthy T, Guruprasad L, Sepuri NBV. A Single Point Mutation in Mitochondrial Hsp70 Cochaperone Mge1 Gains Thermal Stability and Resistance. Biochemistry. 2016 Dec 27;55(51):7065-7072. doi: 10.1021/acs.biochem.6b00232. Epub 2016 Dec 15. PMID: 27977164.
Kumari J, Hussain M, De S, Chandra S, Modi P, Tikoo S, Singh A, Sagar C, Sepuri NB, Sengupta S. Mitochondrial functions of RECQL4 are required for the prevention of aerobic glycolysis-dependent cell invasion. J Cell Sci. 2016 Apr 1;129(7):1312-8. doi: 10.1242/jcs.181297. Epub 2016 Feb 18. PMID: 26906415.
Murari A, Thiriveedi VR, Mohammad F, Vengaldas V, Gorla M, Tammineni P, Krishnamoorthy T, Sepuri NB. Human mitochondrial MIA40 (CHCHD4) is a component of the Fe-S cluster export machinery. Biochem J. 2015 Oct 15;471(2):231-41. doi: 10.1042/BJ20150012. Epub 2015 Aug 14. PMID: 26275620.
Allu PK, Marada A, Boggula Y, Karri S, Krishnamoorthy T, Sepuri NB. Methionine sulfoxide reductase 2 reversibly regulates Mge1, a cochaperone of mitochondrial Hsp70, during oxidative stress. Mol Biol Cell. 2015 Feb 1;26(3):406-19. doi: 10.1091/mbc.E14-09-1371. Epub 2014 Nov 26. PMID: 25428986; PMCID: PMC4310733.
Saikia M, Jobava R, Parisien M, Putnam A, Krokowski D, Gao XH, Guan BJ, Yuan Y, Jankowsky E, Feng Z, Hu GF, Pusztai-Carey M, Gorla M, Sepuri NB, Pan T, Hatzoglou M. Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress. Mol Cell Biol. 2014 Jul;34(13):2450-63. doi: 10.1128/MCB.00136-14. Epub 2014 Apr 21. PMID: 24752898; PMCID: PMC4054315.
Gorla M, Sepuri NB. Perturbation of apoptosis upon binding of tRNA to the heme domain of cytochrome c. Apoptosis. 2014 Jan;19(1):259-68. doi: 10.1007/s10495-013-0915-6. PMID: 24114362.
Marada A, Allu PK, Murari A, PullaReddy B, Tammineni P, Thiriveedi VR, Danduprolu J, Sepuri NB. Mge1, a nucleotide exchange factor of Hsp70, acts as an oxidative sensor to regulate mitochondrial Hsp70 function. Mol Biol Cell. 2013 Mar;24(6):692-703. doi: 10.1091/mbc.E12-10-0719. Epub 2013 Jan 23. PMID: 23345595; PMCID: PMC3596242.
Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner AC, Sepuri NB. The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem. 2013 Feb 15;288(7):4723-32. doi: 10.1074/jbc.M112.378984. Epub 2012 Dec 27. PMID: 23271731; PMCID: PMC3576077.
Sepuri NB, Gorla M, King MP. Mitochondrial lysyl-tRNA synthetase independent import of tRNA lysine into yeast mitochondria. PLoS One. 2012;7(4):e35321. doi: 10.1371/journal.pone.0035321. Epub 2012 Apr 23. PMID: 22539966; PMCID: PMC3335127.
Bansal S, Liu CP, Sepuri NB, Anandatheerthavarada HK, Selvaraj V, Hoek J, Milne GL, Guengerich FP, Avadhani NG. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. J Biol Chem. 2010 Aug 6;285(32):24609-19. doi: 10.1074/jbc.M110.121822. Epub 2010 Jun 7. PMID: 20529841; PMCID: PMC2915697.
Anandatheerthavarada HK, Sepuri NBV, Avadhani NG. Mitochondrial targeting of cytochrome P450 proteins containing NH2-terminal chimeric signals involves an unusual TOM20/TOM22 bypass mechanism. J Biol Chem. 2009 Jun 19;284(25):17352-17363. doi: 10.1074/jbc.M109.007492. Epub 2009 Apr 28. PMID: 19401463; PMCID: PMC2719370.
Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC. Function of mitochondrial Stat3 in cellular respiration. Science. 2009 Feb 6;323(5915):793-7. doi: 10.1126/science.1164551. Epub 2009 Jan 8. PMID: 19131594; PMCID: PMC2758306.
Sepuri NB, Yadav S, Anandatheerthavarada HK, Avadhani NG. Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae--role of protein kinase A in the mitochondrial targeting of CYP2E1. FEBS J. 2007 Sep;274(17):4615-30. doi: 10.1111/j.1742-4658.2007.05990.x. Epub 2007 Aug 14. PMID: 17697118.
Fang JK, Prabu SK, Sepuri NB, Raza H, Anandatheerthavarada HK, Galati D, Spear J, Avadhani NG. Site specific phosphorylation of cytochrome c oxidase subunits I, IVi1 and Vb in rabbit hearts subjected to ischemia/reperfusion. FEBS Lett. 2007 Apr 3;581(7):1302-10. doi: 10.1016/j.febslet.2007.02.042. Epub 2007 Feb 28. PMID: 17349628; PMCID: PMC1995084.
Robin MA, Anandatheerthavarada HK, Biswas G, Sepuri NB, Gordon DM, Pain D, Avadhani NG. Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem. 2002 Oct 25;277(43):40583-93. doi: 10.1074/jbc.M203292200. Epub 2002 Aug 20. PMID: 12191992; PMCID: PMC3800117.
Kovermann P, Truscott KN, Guiard B, Rehling P, Sepuri NB, Müller H, Jensen RE, Wagner R, Pfanner N. Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel. Mol Cell. 2002 Feb;9(2):363-73. doi: 10.1016/s1097-2765(02)00446-x. PMID: 11864609.
And many more to come....